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ABOUT neffy

Get to know neffy, how it works, how to store it, and more.

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Keep neffy with its instructions until ready to use.

SAME EPINEPHRINE,
new device

  • At the first sign of a reaction, get the epinephrine you need fast without a needle.
  • neffy delivers the same epinephrine you'd get from a needle-injector, but it comes in a nasal spray.
  • The epinephrine in neffy affects the body like the epinephrine in a needle-injector, including blood pressure and heart rate.
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HOW neffy WORKS

  • neffy is the only way to deliver epinephrine in a nasal spray for emergency treatment of allergic reactions including anaphylaxis.
  • The epinephrine in neffy is designed to be rapidly absorbed into the nasal passage to reverse the reaction.
  • neffy uses Intravail® technology, which temporarily loosens the spaces between the nasal cells to help epinephrine be absorbed into the body.
  • The nasal spray can get through stuffy noses.
  • Common side effects of neffy include: nasal discomfort, headache, throat irritation, chest and nasal congestion, feeling overly excited, nervous or anxious, nose bleed, nose pain, sneezing, runny nose, dry nose or throat, tingling sensation, including in the nose, feeling tired, dizziness, nausea, and vomiting.

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neffy is designed to be easy to use

  • Count on the neffy device to rapidly and reliably deliver epinephrine, when used as directed.
  • In a study, all 16 adults and 42 children were able to use neffy 2 mg successfully.
Not actual size.
Keep neffy with its instructions until ready to use.

MOST COMMON SIDE EFFECTS

  • Common side effects of neffy include: nasal discomfort, headache, throat irritation, chest and nasal congestion, feeling overly excited, nervous or anxious, nose bleed, nose pain, sneezing, runny nose, dry nose or throat, tingling sensation, including in the nose, feeling tired, dizziness, nausea, and vomiting.
  • In clinical trials, most side effects were mild, although moderate or severe side effects are possible. See full Prescribing Information for a complete list of side effects.
  • Talk to your doctor before using other nasal sprays within 2 weeks of using neffy.
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storage AND handling

  • Each single-use neffy device contains one dose of epinephrine and comes in a blister pack.
  • Your prescription comes with two devices, in case a second dose is needed.

Store neffy at room temperature between 68°F to 77°F (20°C to 25°C). Do not freeze. If neffy freezes, the device will not spray. Storage of neffy at high temperatures up to 122°F (50° C) is allowed for a few days.

neffy 2 mg: 30‑month shelf life for adults and children who weigh 66 lbs or more.

neffy 1 mg: 24‑month shelf life for adults and children aged 4 years and older who weigh 33 lbs to less than 66 lbs.

Be sure to check the expiration date periodically and replace before the expiration date.

neffy CARRYING CASE

Take two neffy devices on the go with this compact carrying case.

Follow the link below to create an account and order your carrying case.

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How to use neffy

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WHAT IS neffy?

neffy is a nasal spray used for emergency treatment of allergic reactions including anaphylaxis, in adults and children aged 4 years and older who weigh 33 lbs or greater.

IMPORTANT SAFETY INFORMATION

What is the most important information that I should know about neffy?

neffy contains epinephrine, a medicine used to treat allergic emergencies (anaphylaxis). Anaphylaxis can be life-threatening, can happen in minutes, and can be caused by stinging and biting insects, allergy injections, foods, medicines, exercise, or other unknown causes.

Always carry two neffy nasal sprays with you because you may not know when anaphylaxis may happen and because you may need a second dose of neffy if symptoms continue or come back. Each neffy contains a single dose of epinephrine. neffy is for use in the nose only.

Use neffy right away, as soon as you notice symptoms of an allergic reaction. If symptoms continue or get worse after the first dose of neffy, a second dose is needed. If needed, administer a second dose using a new neffy in the same nostril starting 5 minutes after the first dose. Get emergency medical help for further treatment of the allergic emergency (anaphylaxis), if needed after using neffy.

Tell your healthcare provider if you have underlying structural or anatomical nasal conditions, about all the medicines you take, and about all your medical conditions, especially if you have heart problems, kidney problems, low potassium in your blood, Parkinson's disease, thyroid problems, high blood pressure, diabetes, are pregnant or plan to become pregnant, or plan to breastfeed.

Tell your healthcare provider if you take or use other nasal sprays or water pills (diuretics) or if you take medicines to treat depression, abnormal heart beats, Parkinson's disease, heart disease, thyroid disease, medicines used in labor, and medicines to treat allergies. neffy and other medications may affect each other, causing side effects. neffy may affect the way other medicines work, and other medicines may affect how neffy works.

What are the side effects of neffy?

neffy may cause serious side effects. If you have certain medical conditions or take certain medicines, your condition may get worse, or you may have more or longer lasting side effects when you use neffy.

Common side effects of neffy include: nasal discomfort, headache, throat irritation, chest and nasal congestion, feeling overly excited, nervous or anxious, nose bleed, nose pain, sneezing, runny nose, dry nose or throat, tingling sensation, including in the nose, feeling tired, dizziness, nausea, and vomiting.

Tell your healthcare provider if you have any side effects that bother you or that do not go away after using neffy.

These are not all of the possible side effects of neffy. Call your healthcare provider for medical advice about side effects. To report side effects, contact ARS Pharmaceuticals Operations, Inc. at 1-877-MY-NEFFY (877-696-3339) or the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see the full Prescribing Information and Patient Information for neffy.

References

  1. neffy [package insert], 03/2025; ARS Pharmaceuticals Operations, Inc.

WHAT IS neffy?

neffy is a nasal spray used for emergency treatment of allergic reactions including anaphylaxis, in adults and children aged 4 years and older who weigh 33 lbs or greater.

IMPORTANT SAFETY INFORMATION

What is the most important information that I should know about neffy?

neffy contains epinephrine, a medicine used to treat allergic emergencies (anaphylaxis). Anaphylaxis can be life-threatening, can happen in minutes, and can be caused by stinging and biting insects, allergy injections, foods, medicines, exercise, or other unknown causes.

Always carry two neffy nasal sprays with you because you may not know when anaphylaxis may happen and because you may need a second dose of neffy if symptoms continue or come back. Each neffy contains a single dose of epinephrine. neffy is for use in the nose only.

Use neffy right away, as soon as you notice symptoms of an allergic reaction. If symptoms continue or get worse after the first dose of neffy, a second dose is needed. If needed, administer a second dose using a new neffy in the same nostril starting 5 minutes after the first dose. Get emergency medical help for further treatment of the allergic emergency (anaphylaxis), if needed after using neffy.

Tell your healthcare provider if you have underlying structural or anatomical nasal conditions, about all the medicines you take, and about all your medical conditions, especially if you have heart problems, kidney problems, low potassium in your blood, Parkinson's disease, thyroid problems, high blood pressure, diabetes, are pregnant or plan to become pregnant, or plan to breastfeed.

Tell your healthcare provider if you take or use other nasal sprays or water pills (diuretics) or if you take medicines to treat depression, abnormal heart beats, Parkinson's disease, heart disease, thyroid disease, medicines used in labor, and medicines to treat allergies. neffy and other medications may affect each other, causing side effects. neffy may affect the way other medicines work, and other medicines may affect how neffy works.

What are the side effects of neffy?

neffy may cause serious side effects. If you have certain medical conditions or take certain medicines, your condition may get worse, or you may have more or longer lasting side effects when you use neffy.

Common side effects of neffy include: nasal discomfort, headache, throat irritation, chest and nasal congestion, feeling overly excited, nervous or anxious, nose bleed, nose pain, sneezing, runny nose, dry nose or throat, tingling sensation, including in the nose, feeling tired, dizziness, nausea, and vomiting.

Tell your healthcare provider if you have any side effects that bother you or that do not go away after using neffy.

These are not all of the possible side effects of neffy. Call your healthcare provider for medical advice about side effects. To report side effects, contact ARS Pharmaceuticals Operations, Inc. at 1-877-MY-NEFFY (877-696-3339) or the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see the full Prescribing Information and Patient Information for neffy.

References

  1. neffy [package insert], 03/2025; ARS Pharmaceuticals Operations, Inc.
ARS Pharmaceuticals Operations, Inc. website

©2025 ARS Pharmaceuticals Operations, Inc. All rights reserved. “ARS Pharma,” the ARS Pharma logo design, “neffy,” the neffy logo, and the neffyconnect logo are trademarks or registered trademarks of ARS Pharmaceuticals Operations, Inc. All other trademarks are the property of their respective owners. NEF‑US‑0046‑8 | 03/2025

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